Driven to save lives after her son's murder, Frankie Kemp has spent years as a non-powered vigilante whom the police choose to overlook, but when a virus releases super-powered potential in much of the population, "Chance" is left to face her child's shadow-sliding killer with nothing more than her wits and experience. Her friend and police detective Darius Murkowski suspects Frankie is getting involved with things she shouldn't, but can't prove it yet, and Chance encounters "superhero" Tazer—a newly-powered man whose good intentions considerably outstrip his ability in a fight.

In the aftermath of fighting Shadowslide, Chance recognizes some of her own mistakes waiting to happen in Candy, a young woman with a drug problem. Saving the girl from an overdose leads to an encounter with the police that escalates out of control; as long as she keeps secrets from Murkowski, he can't help her.

Drug dealer China White unearths Chance's identity. Caught between protecting Candy and saving herself, Chance saves a police officer's life by killing China White and moves herself into the police's limelight. Horrified at having crossed the line into killing, Frankie struggles to keep her identity as Chance a secret, but when super-powered drug courier Crisscross comes after Frankie, she has no choice but to don the mask again. She goes to Tazer for help, but her life as Chance is coming unravelled--and her best friend Nila is about to pay the price. Drug kingpin Carrie Nation knows Frankie's secrets--but so does Detective Murkowski, and it may be his decision that lets Chance continue her work.